Poster Spotlight
June 2008

 

 

Penetration and Efficacy of
Daptomycin in Staphylococcal
Biofilms
by Garth A James1, Judith N Steenbergen2, William M Davison1, Laura L Boegli1, Philip S Stewart1

1Center for Biofilm Engineering Montana State University, Bozeman, MT
2Cubist Pharmaceuticals, Lexington, MA

 

  

Background:  Daptomycin is an effective antibiotic for penetration and killing of Staphylococcal biofilms.  The CBE, in collaboration with Cubist Pharmaceuticals Inc., have measured the penetration of fluorescent-labeled daptomycin into S. epidermidis biofilms using confocal scanning laser microscopy and image analysis.  Also the effectiveness of daptomycin for killing biofilms formed by methicillin-resistant Staphylococcus aureus (MRSA) was compared with several other antibiotics used to treat serious Staphylococcal infections.  Results of these studies were presented by Dr. Garth James at the 2008 American Society for Microbiology General Meeting in Boston, MA.
 

View Poster (pdf)
Copies available on request. Please email gjames(AT)biofilms.montana.edu
 
 
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