Center for Biofilm Engineering
Abstract:
"Measuring Antimicrobial Effects on Biofilm Bacteria: From Laboratory
to Field"
99-034
No Abstract Available
There is no abstract for this chapter. The text below is the first paragraph of
text within the book
Biofilm organisms typically exhibit a high resistance to antimicrobial agents
compared to their planktonic counterparts. Chen and Stewart and Xu et al. showed
that reactive biocides such as hypochlorite and hydrogen peroxide had limited
penetration into a biofilm. Other types of antimicrobials, such as antibiotics,
penetrate quickly into the biofilm but may still have limited efficacy compared
with application of antibiotics to planktonic cells. Studies, in which cells
bearing reporter genes were observed directly by confocal scanning laser
microscopy, have shown that a large number of genes are upregulated as
planktonic cells adhere to a surface and form biofilms. Such genetic
transformations from the planktonic to the sessile state may also play a role in
the antimicrobial resistance of biofilms.
Zelver, N., M. Hamilton, B. Pitts, D. Goeres, D. Walker, P. Sturman,
and J. Heersink, "Measuring Antimicrobial Effects on Biofilm Bacteria: From
Laboratory to Field," in R.J. Doyle, et al. (eds), Biofilms: Methods in
Enzymology, Academic Press, San Diego, CA, 1999, pp.608-628. Abstract 99-034
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