Center for Biofilm Engineering
Abstract:
"Human Leukocytes Adhere, Penetrate, and Respond to Staphylococcus
aureus
Biofilms"
02-047 Staphylococcus aureus is a common pathogen
responsible for nosocomial and community infections. It readily colonizes
indwelling catheters, forming microbiotic communities termed biofilms. S.
aureus bacteria in biofilms are protected from killing by antibiotics and
the body’s immune system. For years, one mechanism behind biofilm resistance to
attack from the immune system’s sentinel leukocytes has been conceptualized as a
deficiency in the ability of the leukocytes to penetrate the biofilm. We
demonstrate here that under conditions mimicking physiological shear, leukocytes
attach, penetrate, and produce cytokines in response to maturing and fully
matured S. aureus biofilm.
Leid, J.G., M.E. Shirtliff, J.W.Costerton, and P. Stoodley, "Human
Leukocytes Adhere, Penetrate, and Respond to Staphylococcus aureus
Biofilms," Infect. and Immun., 70(11): 6339-6345 (2002).
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