Photo of Connie Chang

Office: 11 Chemistry/Biochemistry Bldg. (CBB)
Specialty: Drop-based microfluidics

Dr. Connie Chang joined MSU in November 2013 from a postdoctoral position in the David Weitz laboratory at the School of Engineering and Applied Sciences, Harvard University.

Connie’s research interest is in droplet-based microfluidics, which is the creation and manipulation of tiny drops of fluid that range from picoliters to nanoliters in volume. These drops are created at rates of thousands per second and can be used in applications such as biomaterials, ultra high-throughput screening of bacterial biofilm formation, single cell genomics, and directed evolution in biology.

Chang Research Lab

Courses, Grants, Outreach

Selected Publications

  • Akiyama, T., Williamson, K., Schaefer, R., Pratt, S., Chang, C. B., Franklin, M. (2017) Resuscitation of Pseudomonas aeruginosa from dormancy requires hibernation promoting factor (PA4463) for ribosome preservation. Proceedings of the National Academy of Science: v. 114 i. 12 p. 3204-3209
  • Franklin, M., Chang, C. B., Akiyama, T., Bothner, B. (2015) New Technologies for Studying Biofilms. ASM Press, Biofilms 2nd Edition: p. 1-32
  • Tao, Y., Rotem, A., Zhang, H., Chang, C. B., Basu, A., Kolawole, A. O., Koehler, S. A., Ren, Y., Lin, J. S., ... , ... others, . (2015) Rapid, targeted and culture-free viral infectivity assay in drop-based microfluidics. Lab on a Chip: v. 15 i. 19 p. 3934–3940
  • Chang, C. B., Wilking, J., Kim, S., Shum, H. C., Weitz, D. A. (2015) Monodisperse emulsion drop microenvironments for bacterial biofilm growth. Small: v. 11 i. 32 p. 3954–3961
  • Zhang, H., Cockrell, S. K., Kolawole, A. O., Rotem, A., Serohijos, A. W., Chang, C. B., Tao, Y., Mehoke, T. S., Han, Y., ... , ... others, . (2015) Isolation and Analysis of Rare Norovirus Recombinants from Coinfected Mice Using Drop-Based Microfluidics. Journal of virology: v. 89 i. 15 p. 7722–7734
  • Tao, Y., Rotem, A., Zhang, H., Cockrell, S. K., Koehler, S. A., Chang, C. B., Ung, L. W., Cantalupo, P. G., Ren, Y., ... , ... others, . (2015) Artifact-Free Quantification and Sequencing of Rare Recombinant Viruses by Using Drop-Based Microfluidics. ChemBioChem: v. 16 i. 15 p. 2167–2171
  • Audrey E Fischer, Susan K Wu, Jody BG Proescher,, ., Assaf Rotem, Connie B Chang, Huidan Zhang, Ye Tao, ., , Thomas S Mehoke, Peter M Thielen, Abimbola O, ., Kolawole, Thomas J Smith, Christiane E Wobus, David A, ., Weitz, Jeffrey S Lin, Andrew B Feldman, Joshua T, ., Wolfe, . (2015) A high-throughput drop microfluidic system for virus culture and analysis. Journal of virological methods: v. 213 p. 111–117
  • Chang, C. B., Knobler, C. M., Gelbart, W. M., Mason, T. G. (2008) Curvature dependence of viral protein structures on encapsidated nanoemulsion droplets. Acs Nano: v. 2 i. 2 p. 281–286
  • Hanson, J. A., Chang, C. B., Graves, S. M., Li, Z., Mason, T. G., Deming, T. J. (2008) Nanoscale double emulsions stabilized by single-component block copolypeptides. Nature: v. 455 i. 7209 p. 85–88


Biofilm related publications searchable by author via the CBE Publications Database 

Related News

“MSU professor featured in book about women in workforce”  MSU News Service March 20, 2020

“CBE’s Connie Chang is a pioneer of microfluidics”   Mountains & Minds Dec. 9, 2019

“MSU researchers win $3 million NIH grant to study gut immune system”  MSU News Service Oct. 30, 2019

“Two CBE PhD students collaborate on polymer research”  CBE News July 25, 2019

“CBE researchers, lab featured in women in engineering commercial” MSU News October 30, 2018

“MSU records yet another strong year for research” MSU News Service September 14, 2018 

“MSU researcher wins major award to engineer microbial biofilms”   MSU News Service June 5, 2018 

“MSU researchers receive $1.8 million to study methane-converting microbes”  MSU News Service October 18, 2017

“MSU researcher receives $1.3 million to develop virus-fighting technology”   MSU News Service January 23, 2017