Office: 11 Chemistry/Biochemistry Bldg. (CBB)
Specialty: Microfluidics

Dr. Connie Chang joined MSU in November 2013 from a postdoctoral position in the David Weitz laboratory at the School of Engineering and Applied Sciences, Harvard University.

Connie’s research interest is in droplet-based microfluidics, which is the creation and manipulation of tiny drops of fluid that range from picoliters to nanoliters in volume. These drops are created at rates of thousands per second and can be used in applications such as biomaterials, ultra high-throughput screening of bacterial biofilm formation, single cell genomics, and directed evolution in biology.

Read about the Chang Microfluidics Lab


  • Rapid, targeted and culture-free viral infectivity assay in drop-based microfluidics, Y. Tao, A. Rotem, H. Zhang, C. B. Chang, A. Basu, A. O. Kolawole, S. Koehler, Y. Ren, J. S. Lin, J. M. Pipas, A. B. Feldman, C. Wobus, D. A. Weitz, Lab on a Chip, 10.1039/C5LC00556F (2015).
  • Isolation and Analysis of Rare Norovirus Recombinants from Co-Infected Mice Using Drop-Based Microfluidics, H. Zhang, S. K. Cockrell, A. O. Kolawole, A. Rotem, A. W. R. Serohijos, C. B. Chang, Y. Tao, T. S. Mehoke, Y. Han, J. S. Lin, N. S. Giacobbi, A. B. Feldman, E. Shakhnovich, D. A. Weitz, C. E. Wobus, J. M. Pipas, accepted in Journal of Virology (2015).
  • Monodisperse Emulsion Drop Microenvironments for Bacterial Biofilm Growth, C. B. Chang, J. N. Wilking, S. H. Kim, H. C. Shum, D. A. Weitz, Small, doi:10.1002/smll.201403125 (2015).
  • A High-Throughput Drop Microfluidic System for Virus Culture and Analysis, A. E. Fischer, S. K. Wu, J. B. G. Proescher, A. Rotem, C. B. Chang, H. Zhang, Y. Tao, T. S. Mehoke, P. M. Thielen, A. O. Kolawole, T. J. Smith, C. E. Wobus, D. A. Weitz, J. S. Lin, A. B. Feldman, J. T. Wolfe, J Virol Methods, 213C:111-117 (2014).
  • Shear-Induced Disruption of Dense Nanoemulsion Gels, J. N. Wilking, C. B. Chang, M. M. Fryd, L. Porcar, T. G. Mason, Langmuir, 27, 9 (2011).
  • Nanometer Distance Measurements Between Multicolor Quantum Dots, J. Antelman, C. B. Chang, S. Weiss, X. Michalet, Nano Lett., 9(5), 2199, (2009).
  • Nanoscale Double Emulsions Stabilized by Single Component Block Copolypeptides, J.A. Hanson, C. B. Chang, S.M. Graves, Z. Li, T. G. Mason, T. J. Deming, Nature, 455, 85 (2008).
  • Curvature Dependence of Viral Protein Structures on Encapsidated Nanoemulsion Droplets, C. B. Chang, C. M. Knobler, W. M. Gelbart, T. G. Mason, ACS Nano, 2, 281 (2008).
  • Nanoemulsions: Formation, Structure, and Physical Properties, T. G. Mason, J. N. Wilking, K. Meleson, C. B. Chang, S. M. Graves, J. Phys.: Condens. Matter 18, R635 (2006). Featured in ‘Top Papers 2006 Showcase’
  • Dense Cluster Formation during Aggregation and Gelation of Attractive Slippery Nanoemulsion Droplets, J. N. Wilking, S. M. Graves, C. B. Chang, K. Meleson, M. Y. Lin and T. G. Mason, Phys. Rev. Lett. 96, 015501, (2006). Featured in the Virtual Journal of Nanoscale Science and Technology.
  • Quantification of methylene blue aggregation on a fused silica surface and resolution of individual absorbance spectra, S.M. Ohline, S. Lee, S. Williams, C. Chang, Chem. Phys. Lett. 346, 9, (2001).

Additional biofilm related publications searchable under "Publications" on the left sidebar